Influenza virus neuraminidase: structure, antibodies, and inhibitors.
Identifieur interne : 001D77 ( Main/Exploration ); précédent : 001D76; suivant : 001D78Influenza virus neuraminidase: structure, antibodies, and inhibitors.
Auteurs : P. M. ColmanSource :
- Protein Science : A Publication of the Protein Society [ 0961-8368 ] ; 1994.
Abstract
The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.
Url:
PubMed: 7849585
PubMed Central: 2142611
Affiliations:
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Le document en format XML
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